文章基本信息

标题：Mutagenic DNA Polymerase in Human Leukemic Cells
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作者：Clark F. Springgate ; Lawrence A. Loeb
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：1
页码：245-249
DOI：10.1073/pnas.70.1.245
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Evidence is presented that DNA polymerases from human leukemic cells are mutagenic. Nucleic acid-free extracts of acute lymphoblastic leukemic cells polymerized about 10-times more dCTP using poly(dA-dT){middle dot}poly(dA-dT) as a template than did extracts from normal lymphocytes. Mutagenic DNA polymerases could perhaps play an important role in tumor progression.
关键词：tumor progression ; leukemia ; lymphocytes