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  • 标题:Induction of Cytolysis of Cultured Lymphoma Cells by Adenosine 3′:5′-Cyclic Monophosphate and the Isolation of Resistant Variants
  • 本地全文:下载
  • 作者:Violet Daniel ; Gerald Litwack ; Gordon M. Tomkins
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1973
  • 卷号:70
  • 期号:1
  • 页码:76-79
  • DOI:10.1073/pnas.70.1.76
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Cultured mouse lymphosarcoma cells are killed on exposure to 0.1 mM N6,O2'-dibutyryl-adenosine 3':5'-cyclic monophosphate. A population of cells resistant to the killing effect of dibutyryl cyclic AMP at concentrations as high as 1 mM was selected. The growth characteristics of the resistant cells were similar to those of the sensitive parental line. However, the resistant cells contain less cytoplasmic cyclic AMP-binding proteins and decreased cyclic AMP-stimulated protein kinase activity. It is proposed that transition from sensitivity to resistance to dibutyryl cyclic AMP in lymphoma cells is connected with a modification of the cyclic AMP-binding protein, which appears to be the regulatory subunit of the cyclic AMP-activated protein kinase.
  • 关键词:cytoplasmic receptor molecules ; protein kinase
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