文章基本信息

标题：Acetylcholine Receptors of Muscle Grown In Vitro
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作者：Z. Vogel ; A. J. Sytkowski ; M. W. Nirenberg 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：11
页码：3180-3184
DOI：10.1073/pnas.69.11.3180
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：[125I]Monoiodo- and [125I]diiodo-[α]-bungarotoxin were synthesized and shown to bind specifically to the acetylcholine receptor of cultured embryonic chick- and rat-muscle cells. The pharmacologic properties of the receptor of cultured embryonic chick muscle resembled those of the nicotinic acetylcholine receptor of adult vertebrate muscle. Autoradiography of muscle cells labeled with toxin showed that acetylcholine receptors were distributed over the entire cell surface. In addition, discrete areas with a high receptor concentration were found.
关键词：α-bungarotoxin ; iodination ; cholinergic drugs ; autoradiography