文章基本信息

标题：Karyotypic, Virologic, and Immunologic Analyses of Two Continuous Lymphocyte Lines Established from New Zealand Black Mice: Possible Relationship of Chromosomal Mosaicism to Autoimmunity
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作者：Richard A. Lerner ; Fred Jensen ; Stephen J. Kennel 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：10
页码：2965-2969
DOI：10.1073/pnas.69.10.2965
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Two continuous-suspension lymphocyte lines were isolated from the spleen and fibrosarcoma of a New Zealand Black female mouse. A C-type virus with a density of 1.16 g x cm-3, 70S RNA, and RNA-directed DNA polymerase activity was isolated. The virus was infectious for NRK, NZB, (NZB x NZW)F1, and (NZW x NZW)F1 embryos, and for BALB/c 3T3 cells, but not for NIH Swiss cells. All cells from established lymphocyte cultures, as well as some embryo cells from New Zealand Black mice, showed karyotypic abnormalities. The possibility of chromosomal mosaicism is suggested.
关键词：spleen ; fibrosarcoma ; suspension culture ; RNA oncogenic virus