文章基本信息

标题：Addition of Chemical and Osmotic Free Energies Through Negative Interaction of Protein-Bound Ligands
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作者：Gregorio Weber
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：10
页码：3000-3003
DOI：10.1073/pnas.69.10.3000
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Simple free energy considerations show that an effector ligand, Y, bound to a protein can modify the standard free energy change of the reaction P - X + D - R = P - R + D - X, where P is a protein, D - R a small molecule, and X a group in the protein that interacts negatively with Y. By consideration of a three-compartment system containing the protein, an X-acceptor (A - R), an X-donor (D - X), and the ligand Y present at two different concentrations in the inner and outer compartments, it is shown that the protein can perform under steady-state conditions the addition of the free energy in the Y concentration gradient to that of the chemical reaction A - X + D - R = A - R + D - X. This free energy addition can effectively generate a high energy X-donor from a low energy one and may be of importance in metabolism, particularly in the oxidative phosphorylation of ADP.
关键词：energy coupling ; active transport ; ATP generation ; oxidative phosphorylation