文章基本信息

标题：Dopamine-β-Hydroxylase Activity in Mouse Neuroblastoma Tumors and in Cell Cultures
本地全文：下载
作者：Berta Anagnoste ; Lewis S. Freedman ; Menek Goldstein 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：7
页码：1883-1886
DOI：10.1073/pnas.69.7.1883
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Dopamine-{beta}-hydroxylase activity is present in mouse neuroblastoma C-1300 tumors. The activity is proportional to the weight of the tumor. Serum activity is markedly increased in mice that bear the tumors. Treatment of mice with 5-bromodeoxyuridine causes marked inhibition of tumor growth and decrease of dopamine-{beta}-hydroxylase activity in the serum. The histochemical studies reveal that 1-5% of the cells in mouse C-1300 neuroblastoma tumors contain catecholamines and that catecholamine-containing processes terminate mainly around blood vessels of the tumor. Dopamine-{beta}-hydroxylase is present in clonal neuroblastoma cell lines. The cell line with the greater tendency to form axon-like processes has a higher activity of this enzyme.
关键词：5-bromodeoxyuridine ; catecholamines ; norepinephrine