文章基本信息

标题：Viral-Related RNA in Hodgkins' Disease and Other Human Lymphomas
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作者：R. Hehlmann ; D. Kufe ; S. Spiegelman 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：7
页码：1727-1731
DOI：10.1073/pnas.69.7.1727
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Molecular hybridization with radioactively labeled DNA complementary to the RNA of the Rauscher leukemia virus was used to probe for homologous RNA in human lymphomas. 22 of 32 specimens contained RNA possessing homology to the RNA of the mouse leukemia virus, but not to that of the unrelated viruses causing mammary tumors in mice or myeloblastosis in chickens. Normal adult and fetal tissues failed to show significant levels of the leukemia-specific RNA. It appears that human lymphomas contain RNA sequences homologous to those found in a viral agent known to cause leukemia and lymphomas in an experimental animal. The fact that human leukemias and sarcomas also contain this type of RNA further emphasizes a remarkable similarity between the corresponding neoplasias of murine and human origin.
关键词：DNA-RNA hybridization ; Rauscher murine leukemia virus ; cancer ; neoplasia ; tumor