文章基本信息

标题：Effect of Norepinephrine on Glucose Metabolism in Glioblastoma and Neuroblastoma Cells in Cell Culture
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作者：R. W. Newburgh ; Roger N. Rosenberg
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：7
页码：1677-1680
DOI：10.1073/pnas.69.7.1677
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The addition of norepinephrine to cultured glioblastoma cells results in an inhibition of uptake of radioactivity from D-[2-3H]glucose, D-[1-14C]glucose, D-[2-14C]glucose, and D-[6-14C]glucose. In addition, if the glioblastoma cells are previously labeled with these substrates, norepinephrine causes an increase in the release of radioactivity. These effects were not observed with cultured neuroblastoma cells. It is suggested that the breakdown of glycogen is activated by norepinephrine as a result of an increase in 3':5'-cyclic AMP.
关键词：cyclic AMP ; radioactive glucose ; glycogenolysis ; rat