文章基本信息

标题：Development of Cellular Immunity in the Human Fetus: Dichotomy of Proliferative and Cytotoxic Responses of Lymphoid Cells to Phytohemagglutinin
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作者：Daniel P. Stites ; Martin C. Carr ; H. Hugh Fudenberg 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：6
页码：1440-1444
DOI：10.1073/pnas.69.6.1440
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The reactivity of cells in vitro was investigated with specimens from various lymphoid organs of seven human fetuses. Thymocytes responded to stimulation by phytohemagglutinin with significant increases in synthesis of DNA, but failed to produce destruction of xenogeneic target cells. In cells from bone marrow, precisely the converse pattern of reactivity to the mitogen was detected. Lymphocytes from spleen and peripheral blood demonstrated both phytohemagglutinin-dependent functions, while hepatic cells did not respond to phytohemagglutinin. Based on the striking dichotomy of phytohemagglutinin-dependent responses in fetal thymocytes and bone-marrow lymphoid cells, we conclude that phytohemagglutinin-dependent cytotoxicity and DNA synthesis are functions of different populations of lymphoid cells during human embryonic development.
关键词：T and B cells ; DNA synthesis ; target cells