文章基本信息

标题：Introduction of the 3-Deoxy Group in 3,6-Dideoxyhexoses: A Novel Cofactor Function for Pyridoxamine-5′-Phosphate
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作者：Pedro Gonzalez-Porque ; Jack L. Strominger
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：6
页码：1625-1628
DOI：10.1073/pnas.69.6.1625
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A cofactor needed for the reduction of CDP-4-keto-6-deoxy-D-glucose to CDP-4-keto-3,6-dideoxy D-glucose has been detected and purified. Its spectra in neutral, acid, and basic solutions, its behavior on thin-layer chromatography, and other properties led to its identification as pyridoxamine-5'-phosphate. Moreover, authentic pyridoxamine-5'-phosphate substituted for the purified cofactor with about the same specific activity. Other vitamin B6 derivatives did not stimulate the reaction, and inhibition was observed with some of them.
关键词：vitamin B₆ ; analogues ; purified enzymes ; polysaccharide components