文章基本信息

标题：A Novel DNA Polymerase Activity Found in Association with Intracisternal A-Type Particles
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作者：Samuel H. Wilson ; Edward L. Kuff
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：6
页码：1531-1536
DOI：10.1073/pnas.69.6.1531
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A DNA polymerase activity that promotes the synthesis of poly(dT) has been found in association with intracisternal A-type particles isolated from several mouse tumors. The poly(dT) synthesis activity requires a DNA or RNA primer, is optimal at high salt concentration, prefers magnesium over manganese, and is stimulated by poly(rA). No significant incorporation of dAMP, dGMP, or dCMP was detected in the presence of several RNA and DNA template-primers. The enzyme activity differs in several of its properties from the poly(rA)-directed DNA polymerase activity associated with Rauscher murine leukemia virus.
关键词：DNA synthesis ; tumors ; virus-like particles ; poly(rA) ; myeloma