文章基本信息

标题：Methylxanthine-Induced Escalation: A Propagated Wave Phenomenon Observed in Skeletal Muscle Developing in Culture
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作者：Annette W. Coleman ; John R. Coleman ; James D. Griffin 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：3
页码：613-616
DOI：10.1073/pnas.69.3.613
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Relatively low concentrations of methylxanthines increase spontaneous twitching in cultured muscle fibers; they also cause a second activity, escalation, which is the initiation and undiminished propagation of visible waves. The effect on twitching is abolished by depolarizing concentrations of K+ or by tetrodotoxin; the effect on escalation is not. Escalation is prevented by removal of external Ca++ or by the addition of tetracaine.
关键词：chicken ; tetrodotoxin ; Ca⁺⁺ ; tetracaine ; theophyllin ; aminophyllin