文章基本信息

标题：A Ribosome Dissociation Factor from Rabbit Reticulocytes
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作者：Nicolette H. Lubsen ; Bernard D. Davis
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：2
页码：353-357
DOI：10.1073/pnas.69.2.353
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A ribosome dissociation factor has been detected in an extract of ribosomal particles from rabbit reticulocytes. This factor dissociates free ribosomes from reticulocytes and also from Escherichia coli; it does not dissociate ribosomes complexed with peptidyl-tRNA and mRNA. The reaction appears to be stoichiometric rather than catalytic; it reaches completion in one minute at 37{degrees}C, but is very slow at 0{degrees}C, and it is antagonized and reversed by Mg++. Reticulocyte dissociation factor thus closely resembles that from E. coli. However, the activity has been found primarily associated with the native large subunits rather than the small subunits in lysates.
关键词：fluoride ; E. coli ribosomes ; initiation factors