文章基本信息

标题：The Antibody Response of Mice to Murine Leukemia Virus in Spontaneous Infection: Absence of Classical Immunologic Tolerance
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作者：Michael B. A. Oldstone ; Tadao Aoki ; Frank J. Dixon 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1972
卷号：69
期号：1
页码：134-138
DOI：10.1073/pnas.69.1.134
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Gross murine leukemia virus is the etiologic agent of spontaneous leukemias of AKR mice. Despite the persistence of the Gross virus throughout their life, these mice are not immunologically tolerant to the virus. Specific antibodies to Gross antigens can be detected in the kidney where they have been deposited in the glomeruli, apparently in the form of Gross antigen-antibody complexes.
关键词：AKR mice ; complement-fixing antibodies ; lymphocytic choriomeningitis virus ; immunofluorescence ; glomerular deposits of antigen-antibody complexes