文章基本信息

标题：Immunoglobulin G and Free Kappa-Chain Synthesis in Different Clones of a Hybrid Cell Line
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作者：Behzad Mohit
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：12
页码：3045-3048
DOI：10.1073/pnas.68.12.3045
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：13 clonal cell lines were isolated from a hybrid cell population established by cell fusion between cloned BALB/c myeloma cells that were resistant to 8-azaguanine and produced immunoglobulin G and free kappa chain and C67BL/6n lymphoma cells that were resistant to bromodeoxyuridine and did not produce immunoglobulins. Some of the histocompatibility-2 antigens of both parental cell lines could be demonstrated on all of the hybrid clones. 11 clones synthesized only free kappa chain. Two clones synthesized IgG of BALB/c type, as well as free kappa chain. These clones had higher chromosome number than did the clones that synthesized only kappa chains.
关键词：BALB ; c myeloma cells ; C_[unk] BL ; 6n lymphoma cells ; azaguanine-resistant ; bromodeoxyuridine-resistant