文章基本信息

标题：Transformation of Hamster Cells In Vitro by Polycyclic Hydrocarbons without Cytotoxicity
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作者：J. A. Dipaolo ; P. J. Donovan ; R. L. Nelson 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：12
页码：2958-2961
DOI：10.1073/pnas.68.12.2958
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Treatment with either a flavone or benz()anthracene before the addition of a potent carcinogen, benzo()pyrene or 3-methylcholanthrene, enhanced the transformation of Syrian hamster cells that are seeded in order to form colonies. 7,8-benzoflavone and benz()anthracene prevented the cytotoxicity by the carcinogens, while 5,6-benzoflavone did not. The results clearly indicate that it is possible to dissociate the transforming from the toxic metabolic properties of benzo()pyrene and 3-methylcholanthrene.
关键词：cloning efficiency ; carcinogen ; protective agents ; frequency of transformation