文章基本信息

标题：Addition of Polyadenylate Sequences to Virus-Specific RNA during Adenovirus Replication
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作者：L. Philipson ; R. Wall ; G. Glickman 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：11
页码：2806-2809
DOI：10.1073/pnas.68.11.2806
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Adenovirus-specific nuclear and polysomal RNA, both early and late in the infectious cycle, contain a covalently linked region of polyadenylic acid 150-250 nucleotides long. A large proportion of the adenovirus-specific messenger RNA contains poly(A). As revealed by hybridization experiments, the poly(A) is not transcribed from adenovirus DNA. Furthermore, an adenosine analogue, cordycepin, blocks the synthesis of poly(A) and also inhibits the accumulation of adenovirus messenger RNA on polysomes. Addition of poly(A) to viral RNA may involve a host-controlled mechanism that regulates the processing and transport of messenger RNA.
关键词：HeLa cells ; cordycepin ; DNA-RNA hybridization ; “early” and “late” RNA