文章基本信息

标题：Anti-Antibody Activity of a Monoclonal Macroglobulin
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作者：Noel L. Warner ; Malcolm R. Mackenzie ; H. Hugh Fudenberg 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：11
页码：2846-2851
DOI：10.1073/pnas.68.11.2846
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A monoclonal macroglobulin from a patient with Waldenstrom macroglobulinemia has been shown to have antiglobulin activity of a new type, namely, that of a true anti-antibody. The protein reacts with human, primate, and rabbit IgM and IgG, only when the target immunoglobulin is complexed to an antigen. The implications of the general findings of antiglobulin activity of monoclonal proteins is discussed in relation to the possible etiology of the disease.
关键词：Waldenström's macroglobulinemia ; IgM ; flagellin ; antigen-antibody complexes