文章基本信息

标题：On the Process of Cellular Division in Escherichia coli: Replication of the Bacterial Chromosome Under Control of Prophage P2
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作者：Gunnar Lindahl ; Yukinori Hirota ; François Jacob 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：10
页码：2407-2411
DOI：10.1073/pnas.68.10.2407
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The temperature-sensitive mutant CRT46 of Escherichia coli K12 is unable to initiate new rounds of DNA replication at 42{degrees}C. Mutants of bacteriophage P2 have been isolated, which, in the prophage state, allow mutant CRT46 to grow at 42{degrees}C. The lysogenic bacteria that grow at 42{degrees}C are apparently replicating under the control of prophage P2, which substitutes for the bacterial initiation system. The ability of prophage P2 cause this suppression phenomenon depends on the position of the prophage on the bacterial chromosome. Those lysogenic strains that are able to grow at 42{degrees}C all carry the prophage close to metE. The P2 mutants that allow CRT46 to grow at 42{degrees}C have insertions in the early region of the P2 genome. The suppression requires the cis-acting protein formed by gene A of P2.
关键词：mutants ; met E ; cis -acting protein ; lysogenic bacteria