文章基本信息

标题：Helper Activity of Human Leukemic Tissue Extracts for Leukemia Virus Expression in Mice
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作者：Richard A. Steeves ; Audrey Fjelde ; Edwin A. Mirand 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：10
页码：2391-2395
DOI：10.1073/pnas.68.10.2391
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Extracts of cultured human leukemic tissues increased the spleen focus-forming activity of Friend leukemia virus preparations in BALB/c and other partially resistant mice. Such mice carry the Fv-1b gene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows co-infecting leukemia viruses of mice, cats, or chickens to substitute for the inhibited helper virus and increase the expression of the spleen focus-forming virus. The helper activity of extracts from human leukemic tissues shared several important properties with that associated with known leukemogenic viruses of animals.
关键词：BALB ; c mice ; Fv-1^b gene ; Friend virus complex ; spleen focus-forming virus