文章基本信息

标题：Activation and Isolation of Hamster-Specific C-Type RNA Viruses from Tumors Induced by Cell Cultures Transformed by Chemical Carcinogens
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作者：Aaron E. Freeman ; Gary J. Kelloff ; Raymond V. Gilden 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：10
页码：2386-2390
DOI：10.1073/pnas.68.10.2386
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Cell cultures of Syrian hamster embryo were treated for 7 days with selected chemicals. Certain cultures were morphologically transformed by three different chemical preparations and yielded cell lines that subsequently produced malignant tumors in hamsters. Although the cell lines were negative for infectious virus before inoculation into animals, hamster-specific C-type RNA virus was isolated from tumors or from cell lines derived from the tumors. Since infectious C-type viruses are usually not demonstrable in hamster tissues of normal or tumor origin, we conclude that the chemical treatment and activation of the viruses are related events.
关键词：hamster-embryo fibroblasts ; 3-methylcholanthrene ; cigarette-smoke condensate