文章基本信息

标题：Stimulation of the Proliferation of Chicken Fibroblasts by Folic Acid or a Serum Factor(s) in a Plasma-Containing Medium
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作者：Samuel D. Balk
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：8
页码：1689-1692
DOI：10.1073/pnas.68.8.1689
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The proliferation of chicken fibroblasts is strongly stimulated by folic acid, at greater than physiological concentrations, in a plasma-containing medium, or by serum in a medium of physiological folic acid concentration. Serum and plasma, however, do not appear to differ in their content of folic acid derivatives. A qualitative difference between the proliferative behaviors of normal and transformed fibroblasts is obtained when these cells are cultivated in a physiological-folate-low-calcium-plasma medium. In such a medium, transformants proliferate steadily, at a significant rate, while normal fibroblasts do not multiply at all.
关键词：calcium ; transformed fibroblasts