文章基本信息

标题：Divergence between Immunosuppression and Immunocompetence during Virus-Induced Leukemogenesis
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作者：Jan Cerny ; Robert F. McAlack ; Walter S. Ceglowski 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：8
页码：1862-1865
DOI：10.1073/pnas.68.8.1862
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Mice were infected with Friend leukemia virus and later immunized with either Vibrio cholerae vaccine or sheep erythrocytes. The primary antibody response to the bacteria (as judged by the number of plaque-forming cells) was slightly enhanced by the viral infection, whereas the response to sheep erythrocytes was inhibited. The difference appeared due to sensitization of mice to antigens crossreacting with those of sheep erythrocytes; no natural immunity to V. cholerae is detectable. However, the response of mice infected with Friend leukemia virus to a secondary challenge with the cholera bacteria was markedly inhibited. Even though the number of plaque-forming cells during the primary response was not reduced, accumulation of the cells in distinct splenic foci was suppressed. These results suggest that the effect of Friend leukemia virus on immunocompetent cells is selective. The immune response appears to be susceptible to leukemia virus-induced immunosuppression only when there has been a previous stimulation of immunocytes by antigen.
关键词：mice ; Friend leukemia virus ; Vibrio cholerae ; sheep erythrocytes