文章基本信息

标题：Cytoplasmic DNA synthesis Induced by RNA Tumor Viruses
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作者：M. Hatanaka ; T. Kakefuda ; R. V. Gilden 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：8
页码：1844-1847
DOI：10.1073/pnas.68.8.1844
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Infection of mouse embryo cells with two strains of murine sarcoma virus and one strain of murine leukemia virus was followed rapidly by synthesis of DNA in the cytoplasm. Persistently infected cells have not shown such synthesis, and ultraviolet-irradiated virus did not induce DNA synthesis. This new DNA presumably represents an intermediate in the virus replication cycle specified by the virion DNA polymerase(s). Failure to observe cytoplasmic DNA synthesis in persistently infected cells suggests, in keeping with the results of inhibitor experiments, that the new "viral" DNA becomes associated with cellular DNA in some form of stable interaction.
关键词：mouse embryo fibroblasts ; murine sarcoma virus ; Rauscher murine leukemia virus ; autoradiography