首页    期刊浏览 2024年12月06日 星期五
登录注册

文章基本信息

  • 标题:Interchain and Intrachain Disulfide Bridges of a Human Immunoglobulin M: Detection of a Unique Fragment
  • 本地全文:下载
  • 作者:B. Frangione ; F. Prelli ; C. Mihaesco
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1971
  • 卷号:68
  • 期号:7
  • 页码:1547-1551
  • DOI:10.1073/pnas.68.7.1547
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Studies of the amino acid sequences around half-cystine residues in an immunoglobulin M have revealed an unexpectedly high number. At least 14 different sequences were found in the {micro} chain (VHIII subclass). Four of these were involved in interchain disulfide bridges and at least 10 in intrachain bridges. Five came from the {kappa} chain ({kappa}III subclass, Inv b). Several others, although having a high degree of homology, were not identical with those of either the {micro} or {kappa} chains. These results support the concept of an additional fragment in {gamma}M molecules, although its function and localization remain to be determined.
国家哲学社会科学文献中心版权所有