文章基本信息

标题：Serologic Evidence that a Herpes-Type Virus is the Etiologic Agent of Heterophile-Positive Infectious Mononucleosis
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作者：Berge Hampar ; Konrad C. Hsu ; Lidia M. Martos 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：7
页码：1407-1411
DOI：10.1073/pnas.68.7.1407
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The antibody activity against herpes-type virus (HTV) of heterophile-positive infectious mononucleosis sera and "normal" sera from humans was determined with immunoferritin. The antiviral activity of the mononucleosis sera was associated with the IgM antibodies, while the antiviral activity of the "normal" human sera was associated with the IgG antibodies. It was concluded from these findings that the appearance of antibodies to herpes-type virus in heterophile-positive sera represents a primary immunogenic exposure to this virus, or to a serologically related virus. This conclusion, in turn, suggests that herpes-type virus or a serologically related virus is the etiologic agent of heterophile-positive mononucleosis.
关键词：human ; rabbit ; purified antibodies ; antisera ; blocking ; electron microscopy