文章基本信息

标题：Analysis of the Events Leading to SV40-Induced Chromosome Replication and Mitosis in Primary Mouse Kidney Cell Cultures
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作者：Evelyne May ; Pierre May ; Roger Weil 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：6
页码：1208-1211
DOI：10.1073/pnas.68.6.1208
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Abortive infection with simian virus 40 in confluent, "contact-inhibited", mouse kidney cell cultures was studied. The sequential events, in individual cells, are tentatively represented by the simplified scheme: (a) transcription of early virus-specific (messenger) RNA; (b) appearance of T-antigen; (c) [psychrosensitive event(s)]; (d) chromosome replication; (e) normal or abnormal mitosis. No evidence for the replication of viral progeny DNA was obtained. The sequence of the events (a)-(d) is analogous to that observed in contact-inhibited mouse kidney tissue culture cells during lytic infection with polyoma virus.
关键词：induced chromosome replication ; mitosis ; T-antigen ; autoradiography