文章基本信息

标题：A Unique Synaptosomal Fraction, Which Accumulates Glutamic and Aspartic Acids, in Brain Tissue
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作者：Alan R. Wofsey ; Michael J. Kuhar ; Solomon H. Snyder 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1971
卷号：68
期号：6
页码：1102-1106
DOI：10.1073/pnas.68.6.1102
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Subcellular fractionation of rat cerebral cortical slices on sucrose density gradients provides evidence for the existence of a unique synaptosomal fraction (enriched in pinched-off nerve endings) that selectively accumulates glutamic and aspartic acids. The particles in this fraction sediment to a less dense portion of sucrose gradients than do particles that accumulate aromatic, basic, and neutral (large and small) amino acids. Particles that store gamma-aminobutyric acid are even less dense than those that contain exogenous glutamic and aspartic acids. The distribution of endogenous glutamic acid encompasses both that of exogenous glutamic acid and that of the neutral and basic amino acids. These findings provide neurochemical support for the suggestion that glutamic and/or aspartic acid has a specialized synaptic function, perhaps as a neurotransmitter, in the mammalian brain.
关键词：rat ; rabbit ; neurotransmitters ; sucrose density gradients