文章基本信息

标题：The Selective Inhibition of Protein Initiation by T4 Phage-Induced Factors
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作者：Edward B. Klem ; Wen-Tah Hsu ; Samuel B. Weiss 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1970
卷号：67
期号：2
页码：696-701
DOI：10.1073/pnas.67.2.696
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The phenomenon of selective translation of T4 template RNA by ribosomes from T4-infected cells, or factors derived therefrom, has been extended to studies on the initiation of protein synthesis. A high-salt extract derived from T4-infected ribosomes inhibits the formation of initiation complexes of MS2 and Escherichia coli template RNA with uninfected ribosomes while efficiently supporting the formation of initiation complexes with T4 template RNA. T4 factors also permit T5 template RNA to bind to E. coli ribosomes, which indicates that the T4 selective effect is not exclusive for T4 templates. Other evidence indicates that T4 factors do not alter the process of polypeptide chain elongation.