文章基本信息

标题：Induction of δ-Aminolevulinic Acid Synthetase in Chick Embryo Liver Cells in Culture
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作者：Shigeru Sassa ; S. Granick
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1970
卷号：67
期号：2
页码：517-522
DOI：10.1073/pnas.67.2.517
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：{delta}-Aminolevulinic acid synthetase is induced in chick embryo liver culture by the natural steroid, etiocholanolone, and by the foreign chemical, 3,5-dicarbethoxy-1,4-dihydrocollidine at the level of transcription. Alternatively, inducing chemicals such as allylisopropylacetamide and {gamma}-hexachloro-cyclohexane act primarily at the level of translation. Hemin (Ki = 5 {micro}M) inhibits the induction at the level of translation. In liver cell culture, the half-life of {delta}-aminolevulinic acid synthetase is 3 hr, that of mRNA about 5 hr.