文章基本信息

标题：Regulation of Cellular Interferon Production: Enhancement by Antimetabolites
本地全文：下载
作者：Y. H. Tan ; John A. Armstrong ; Y. H. Ke 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1970
卷号：67
期号：1
页码：464-471
DOI：10.1073/pnas.67.1.464
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Cycloheximide, at a protein-inhibitory concentration, when given to rabbit kidney cell cultures that had been exposed either to UV-irradiated Newcastle Disease virus or to a complex of polyinosinic and polycytidylic acids (poly I{middle dot}poly C), enhanced the production of interferon. The enhancement was greater if, in addition to cycloheximide, the cells were also treated with actinomycin D. On the basis of these findings, a mechanism, consisting primarily of the production of a control protein which normally checks interferon production, is postulated for interferons stimulated by these two substances.