文章基本信息

标题：Role of Adrenal Cortical Function in Toxicity of Polyriboinosinic·Polyribocytidylic Acid and Its Component Homopolymers
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作者：Morris S. Zedeck ; Hans Marquardt ; Stephen S. Sternberg 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1970
卷号：67
期号：1
页码：180-184
DOI：10.1073/pnas.67.1.180
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Adrenalectomized rats are 1000 times more sensitive to lethal effects of the double-stranded complex polyriboinosinic{middle dot}polyribocytidylic acid than intact rats. They are protected from such lethal effects by corticosterone. The complex can rapidly induce diffuse, severe necrosis of villous epithelium in small intestine without damage in crypts. Injection of the individual homopolymers, polyriboinosinic acid and polyribocytidylic acid, separately but in rapid succession is at least as lethal as injection of the complex.