文章基本信息

标题：Peptide Chain Termination with Mammalian Release Factor
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作者：J. L. Goldstein ; A. L. Beaudet ; C. T. Caskey 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1970
卷号：67
期号：1
页码：99-106
DOI：10.1073/pnas.67.1.99
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We report a method for the in vitro study of peptide chain termination in mammals. A proteinaceous release factor has been isolated from rabbit reticulocyte extracts. This factor and a polyribonucleotide template containing the bases U and A stimulate the release of N-formylmethionine from mammalian [N-formylmethionyl-tRNAf{middle dot}ribosome] intermediates. Our studies suggest that UAA is a terminator codon for mammalian cells.