文章基本信息

标题：MAPPING OF A HUMAN GENETIC REGULATOR ELEMENT BY SOMATIC CELL GENETIC ANALYSIS
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作者：Robert J. Klebe ; Tchaw-ren Chen ; Frank H. Ruddle 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1970
卷号：66
期号：4
页码：1220-1227
DOI：10.1073/pnas.66.4.1220
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The ES-2 esterase is a kidney-associated esterase and is expressed in a cloned mouse renal adenocarcinoma cell line. Somatic cell hybridization of the mouse renal adenocarcinoma with either mouse or human fibroblasts leads to the marked reduction of ES-2 esterase titer. The extinction of ES-2 esterase activity in mousexhuman hybrids is reversible. Extinction correlates with the presence of the human C10 chromosome in the somatic cell hybrids; whereas reexpression of the ES-2 esterase is observed in hybrids which have lost C10. Thus, the proposed regulator element involved is probably structurally linked to C10; however, linkage to a member of the D or G groups cannot be completely excluded.