文章基本信息

标题：GENETIC CONTROL OF THE IMMUNE RESPONSE OF GUINEA PIGS TO LIMITING DOSES OF BOVINE SERUM ALBUMIN: RELATIONSHIP TO THE POLY-L-LYSINE GENE
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作者：I. Green ; J. K. Inman ; B. Benacerraf 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1970
卷号：66
期号：4
页码：1267-1274
DOI：10.1073/pnas.66.4.1267
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The response of strain 2 guinea pigs to limiting doses of bovine serum albumin is under dominant genetic control linked with the poly-L-lysine gene. Inbred strains 2 and 13 guinea pigs make similar antibody responses to 10 {micro}g bovine serum albumin, whereas strain 2 but not strain 13 animals produce significant amounts of antibodies in response to 0.1 {micro}g. The relationship between the presence of the poly-L-lysine gene and the ability to respond to limiting doses of bovine serum albumin has also been investigated in random-bred Hartley strain guinea pigs.