文章基本信息

标题：Duplication of large genomic regions during the evolution of vertebrate homeobox genes
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作者：K Schughart ; C Kappen ; F H Ruddle 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1989
卷号：86
期号：18
页码：7067-7071
DOI：10.1073/pnas.86.18.7067
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The phylogenetic relationships of 21 murine Antp-class (Drosophila mutation Antennapedia-type class) homeobox genes have been analyzed, and several groups of related genes have been identified. The murine Antp-class homeobox genes are localized within four gene clusters. The similar structural organization of the four gene clusters strongly suggests that genes within a group of related Antp-class homeobox genes are derived from duplications of large genomic regions. After the duplication, the gross structures of the homeobox gene clusters have been maintained over a long period of evolutionary time, indicating that the specific organization of genes within a cluster may be of functional importance.