文章基本信息

标题：Conservation of the human telomere sequence (TTAGGG)n among vertebrates
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作者：J Meyne ; R L Ratliff ; R K Moyzis 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1989
卷号：86
期号：18
页码：7049-7053
DOI：10.1073/pnas.86.18.7049
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：To determine the evolutionary origin of the human telomere sequence (TTAGGG)n, biotinylated oligodeoxynucleotides of this sequence were hybridized to metaphase spreads from 91 different species, including representative orders of bony fish, reptiles, amphibians, birds, and mammals. Under stringent hybridization conditions, fluorescent signals were detected at the telomeres of all chromosomes, in all 91 species. The conservation of the (TTAGGG)n sequence and its telomeric location, in species thought to share a common ancestor over 400 million years ago, strongly suggest that this sequence is the functional vertebrate telomere.