文章基本信息

标题：Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase
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作者：J D Robishaw ; D W Russell ; B A Harris 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1986
卷号：83
期号：5
页码：1251-1255
DOI：10.1073/pnas.83.5.1251
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A bovine adrenal cDNA clone encoding the entire alpha subunit of the GTP-binding regulatory protein that stimulates adenylate cyclase (Gs) was isolated and sequenced. This cDNA directed the synthesis of the larger, 52-kDa form of the polypeptide in COS cells, even though the clone appeared to encode a 46-kDa protein. Comparison of the deduced amino acid sequence of Gs alpha with the alpha subunit of another G protein, transducin, revealed striking homologies.