文章基本信息

标题：Aberrant neurofilament phosphorylation in Alzheimer disease
本地全文：下载
作者：N H Sternberger ; L A Sternberger ; J Ulrich 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1985
卷号：82
期号：12
页码：4274-4276
DOI：10.1073/pnas.82.12.4274
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Alzheimer tangles, despite their location in neuronal perikarya, react immunocytochemically with monoclonal antibodies to phosphorylated epitopes of neurofilaments. Normal perikarya do not contain phosphorylated neurofilaments. The aberrant phosphorylation in both plaques and tangles seems to be largely restricted to individual phosphorylation sites among the many sites available in neurofilaments. It is suggested that the Alzheimer lesion involves an imbalance within specific kinases responsible for phosphorylation of different sites in neurofilaments.