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标题：Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum
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作者：E F Roth ; C Raventos-Suarez ; A Rinaldi 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1983
卷号：80
期号：1
页码：298-299
DOI：10.1073/pnas.80.1.298
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Glucose-6-phosphate dehydrogenase (G6PD; EC 1.1.1.49 )-deficient red blood cells from male hemizygotes and female heterozygotes from the island of Sardinia were studied for their ability to support growth in vitro of the malaria-causing organism Plasmodium falciparum. Parasite growth was approximately one-third of normal in both hemi- and heterozygotes for G6PD deficiency. In Sardinians with the beta 0-thalassemia trait, parasite growth was normal except when G6PD deficiency occurred together with the thalassemia trait. The data support the hypothesis that G6PD deficiency may confer a selective advantage in a malarious area; the female heterozygote may be at a particular advantage because resistance to malaria equals that of male hemizygotes, but the risk of fatal hemolysis may be less. However, more female heterozygotes must be studied to confirm this hypothesis. No protective effect of beta 0-thalassemia trait could be demonstrated in vitro.