文章基本信息

标题：Sleep-promoting effects of muramyl peptides
本地全文：下载
作者：J M Krueger ; J R Pappenheimer ; M L Karnovsky 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1982
卷号：79
期号：19
页码：6102-6106
DOI：10.1073/pnas.79.19.6102
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A muramyl peptide that induces excess slow-wave sleep in rats, rabbits, and cats has recently been isolated from human urine. We now report that synthetic acetylmuramyl-L-alanyl-D-isoglutamine ("muramyl dipeptide") and its lysyl derivative (acetylmuramyl-L-alanyl-D-isoglutaminyllysine) can mimic the somnogenic effects of the natural peptide. Both compounds are also pyrogenic and may cause other disturbances of autonomic function. The pyrogenic effects of intravenously administered muramyl dipeptide can be suppressed by previous treatment with acetaminophen without blocking the sleep-promoting effects.