文章基本信息

标题：Similarity of secretory protein I from parathyroid gland to chromogranin A from adrenal medulla
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作者：D V Cohn ; R Zangerle ; R Fischer-Colbrie 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1982
卷号：79
期号：19
页码：6056-6059
DOI：10.1073/pnas.79.19.6056
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We have compared the amino acid and carbohydrate compositions, partial amino acid sequences, immunological crossreactivity, and physical properties of secretory protein I of the parathyroid gland and chromogranin A of adrenal gland. This comparison indicates that these proteins are similar molecules. Because secretory protein I is present in secretory granules containing parathormone and is cosecreted with the hormone, and because chromogranin A is contained within chromaffin granules and, likewise, is secreted with the catecholamines, the present observations raise the possibility that this class of protein plays a general role in hormone secretion or storage mechanisms.