文章基本信息

标题：Nonrandom distribution of repeated DNA sequences with respect to supercoiled loops and the nuclear matrix
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作者：D Small ; B Nelkin ; B Vogelstein 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1982
卷号：79
期号：19
页码：5911-5915
DOI：10.1073/pnas.79.19.5911
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The DNA in a eukaryotic nucleus is arranged into a series of supercoiled loops that are anchored at their bases to the nuclear matrix. We have analyzed the DNA sequences that are closest to the matrix attachment points for their relative content of specific repeated sequences. Sequences were enriched (mouse satellite, human Alu family) or depleted (mouse EcoRI repeat, monkey alpha component), depending on the specific sequence and species examined. These results can be understood in terms of a nonrandom arrangement of DNA sequences with respect to nuclear DNA loops.