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  • 标题:NMR chemical shift imaging in three dimensions
  • 本地全文:下载
  • 作者:T R Brown ; B M Kincaid ; K Ugurbil
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1982
  • 卷号:79
  • 期号:11
  • 页码:3523-3526
  • DOI:10.1073/pnas.79.11.3523
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:A method for obtaining the three-dimensional distribution of chemical shifts in a spatially inhomogeneous sample using Fourier transform NMR is presented. The method uses a sequence of pulsed field gradients to measure the Fourier transform of the desired distribution on a rectangular grid in (k,t) space. Simple Fourier inversion then recovers the original distribution. An estimated signal/noise ratio of 20 in 10 min is obtained for an "image" of the distribution of a 10 mM phosphorylated metabolite in the human head at a field of 20 kG with 2-cm resolution.
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