文章基本信息

标题：Thymosins beta 8 and beta 9: two new peptides isolated from calf thymus homologous to thymosin beta 4
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作者：E Hannappel ; S Davoust ; B L Horecker 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1982
卷号：79
期号：6
页码：1708-1711
DOI：10.1073/pnas.79.6.1708
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Two new peptides, designated thymosin beta 8 and thymosin beta 9, respectively, have been isolated and their amino acid sequences established. Thymosin beta 8, isolated from calf thymus fraction 5, has a mass of 4518 daltons and contains 39 amino acid residues, of which 31 are identical to the corresponding amino acid residues in thymosin beta 4 isolated from the same source. The NH2 terminus of thymosin beta 8 is acetylalanine, compared with acetylserine in thymosin beta 4. Thymosin beta 9, isolated from fresh-frozen calf thymus by a procedure that minimizes proteolysis, is identical to thymosin beta 8 except for the presence of an additional dipeptide, -Ala-LysOH, at the COOH terminus. It has a mass of 4717 daltons and 32 of its 41 amino acids are identical to those of thymosin beta 4. The similarity in structures of thymosin beta 4 and thymosin beta 9 suggests that they may have related functions.