文章基本信息

标题：Exon/intron organization and complete nucleotide sequence of an HLA gene
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作者：M Malissen ; B Malissen ; B R Jordan 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1982
卷号：79
期号：3
页码：893-897
DOI：10.1073/pnas.79.3.893
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We have isolated and determined the sequence of a genomic clone containing the gene for a human class I transplantation antigen. The gene contains seven exons. The first five exons code respectively for a signal peptide, for the first, second, and third extracellular domains of the protein molecule, and for the transmembrane region. The cytoplasmic segment is encoded by part of the fifth and the sixth and the seventh exons. The structure of the protein encoded by this unit is closely homologous with known class I transplantation antigens.