文章基本信息

标题：Autosomal dominant aniridia: probable linkage to acid phosphatase-1 locus on chromosome 2
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作者：R E Ferrell ; A Chakravarti ; H M Hittner 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1980
卷号：77
期号：3
页码：1580-1582
DOI：10.1073/pnas.77.3.1580
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Maximum likelihood analysis for linkage between autosomal dominant aniridia and 12 biochemical and serological markers in a single large family showed a probable linkage between autosomal dominant aniridia and the enzyme acid phosphatase-1. The presence of an autosomal dominant aniridia gene linked to acid phosphatase-1 on chromosome arm 2p and the existence of an aniridia syndrome resulting from deletion of band 13 of the short arm of chromosome 11 establishes a chromosome basis for genetic heterogeneity of aniridia phenotypes.