文章基本信息

标题：Tamoxifen prevents induction of hepatic neoplasia by zeranol, an estrogenic food contaminant.
本地全文：下载
作者：J E Coe ; K G Ishak ; J M Ward 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1992
卷号：89
期号：3
页码：1085-1089
DOI：10.1073/pnas.89.3.1085
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Zeranol (alpha-zearalanol) is a beta-resorcylic acid lactone (RAL) that has estrogen activity. It is synthesized by molds and is difficult to avoid in human food products. We tested the ability of this mycoestrogen to damage the liver of the Armenian hamster, a rodent that is especially sensitive to hepatotoxic effects of exogenous estrogens. Zeranol induced acute hepatotoxicity and, subsequently, hepatic carcinogenesis; both effects were blocked by tamoxifen, suggesting estrogen receptor mediation. Because zeranol is acting alone as a primary initiator of hepatic neoplasms, this model provides an unusual opportunity to study the pathogenesis of estrogen-initiated tumorigenesis.