文章基本信息

标题：Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element
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作者：P Leroy ; H Nakshatri ; P Chambon 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1991
卷号：88
期号：22
页码：10138-10142
DOI：10.1073/pnas.88.22.10138
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We have characterized the promoter of the mouse retinoic acid receptor alpha 2 (mRAR-alpha 2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-beta 2 promoter. Moreover, RAR-alpha 2 and RAR-beta 2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-alpha 2 RARE consists of two directly repeated 5'-GTTCA-3' motifs to which all three RARs (alpha, beta, and gamma) bind in vitro.