文章基本信息

标题：A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce
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作者：R Delgado ; P Hidalgo ; F Diaz 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1991
卷号：88
期号：2
页码：557-560
DOI：10.1073/pnas.88.2.557
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Single-channel recording from longitudinal ventrolateral Drosophila larval muscle reveals the presence of a potassium-selective channel that is directly and reversibly activated by cAMP in a dose-dependent fashion. Activation is specific and it cannot be mimicked by a series of agents that include AMP, cGMP, ATP, inositol trisphosphate, and Ca2+. Channel current records obtained from larval muscle in different dunce mutants possessing abnormally high levels of cAMP show that, in the mutants, the channel displays an increased probability of opening.